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Questions about tolerance with use of opioids.

Publication: The Journal of Musculoskeletal Medicine
Publication Date: 01-AUG-08
Format: Online
Delivery: Immediate Online Access
Full Article Title: Questions about tolerance with use of opioids.(Q & A: Practical answers to your clinical questions)(Letter to the editor)

Article Excerpt
I was very interested in the article "Chronic pain update: Addressing abuse and misuse of opioid analgesics" by Ross et al (The Journal of Musculoskeletal Medicine, June 2008, page 268) because pain management and addiction medicine is my specialty. The article was interesting, useful, and well written and referenced. However, it perpetuated one myth about opioid prescribing for chronic pain when the authors wrote, "Tolerance develops in most patients who receive long-term opioid therapy."

Not surprisingly, this statement--in contrast to most other declarations of fact in the article--was not referenced. In my many years of experience treating patients with chronic pain with opioids, as well as the experience of other clinicians who prescribe opioids over long periods, tolerance to...

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