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Article Excerpt
ABSTRACT: Osteopoikilosis is a rare, benign osteosclerotic dysplasia that predominantly involves the appendicular skeleton. Radiographic findings are diagnostic, and the disease often is discovered incidentally on x-ray films. The importance of recognizing osteopoikilosis lies in differentiating it from osteoblastic metastases. The cause is unclear. Patients typically are asymptomatic. Diagnostic findings include the appearance of numerous small, well-defined, spheroid sclerotic foci. Because evidence suggests an association with skeletal and dermatological changes, evaluation for coexisting pathological conditions may be warranted. The differential diagnosis for a patient who has radiographic characteristics similar to those of osteopoikilosis includes osteoblastic metastases, mastocytosis, tuberous sclerosis, melorheostosis, and osteopathia striata. (J Musculoskel Med. 2008;25:387-389)
Osteopoikilosis, which literally means "spotted bones," is a rare, benign osteosclerotic dysplasia that was first described in the early 20th century. (1-5) The disease, seen in men and women of all ages, predominantly involves the appendicular skeleton. It occurs most often in bones of the hands and feet, although lesions are seen scattered around larger joints. (3,5,6) The pathogenesis is unknown, although mutations in the LEMD3 gene may be the cause. (7,8)
Radiographic findings are diagnostic, and the disease often is discovered incidentally on x-ray films. Medical evaluation may be important, however, because there may be coexisting developmental or pathological conditions. (9)
The importance of recognizing osteopoikilosis lies in differentiating it from osteoblastic metastases. (2) Gaining a...
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