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...side of the face and BPO 5%/clindamycin 1% combination product on the contralateral side, twice daily for 4 weeks.
Results: Of 23 patients enrolled, 100% completed the study. Reductions in lesion count with the solubilized BPO gel were at least as great as with BPO/clindamycin--and significantly greater (P< 05) for noninflammatory lesions at week 1 and inflammatory lesions at week 4- Both regimens were generally well tolerated and patient satisfaction was comparable.
Conclusions: Solubilized BPO 5% gel monotherapy offers significantly greater efficacy, and comparable patient satisfaction, compared with BPO/clindamycin. The early reduction in lesion counts observed with the solubilized BPO gel in the absence of an antibiotic is clinically relevant.
Introduction
Benzoyl peroxide (BPO) can be effective in the treatment of both inflammatory and noninflammatory acne lesions, (1) presumably as a result of its antibacterial and comedolytic activities. It has a key advantage over antibiotics as it is not associated with the development of bacterial resistance. (2) However, BPO is poorly soluble and molecules tend to aggregate together to form crystalline clusters. Commercially available formulations of BPO are generally emulsions of these clusters of which most of the BPO is trapped in the interior of the clusters. As a result, the bioavailability of BPO, and its ability to interact with Projnonihacteriinn acnes (P acnes), is compromised. The size of the clusters can also hinder their passage into hair follicles and, in addition, some commercially successful formulations have vehicles that further inhibit the ability of BPO to penetrate inside hair follicles.
Using a patented technology, 2 novel formulations of solu bilized BPO 5% (a gel and a lotion) have now been developed that aim to maximize the bioavailability of BPO and enhance its follicular penetration. In a split-face randomized study evaluating intrafollicular bactericidal activity, the solubilized BPO 5% was shown to achieve a greater reduction in colony forming units of...
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