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Acute pneumonitis after in vitro fertilization with IM progesterone.

Publication: Journal of Respiratory Diseases
Publication Date: 01-APR-08
Format: Online
Delivery: Immediate Online Access
Full Article Title: Acute pneumonitis after in vitro fertilization with IM progesterone.(A CASE IN POINT)(intramuscular)(Case study)

Article Excerpt
The authors describe a case of acute eosinophilic pneumonia that appeared to be associated with infertility treatment.

The case

A 34-year-old woman presented to the hospital with low-grade fever, fatigue, dyspnea with minimal exertion, and dry cough. She had emigrated from China 3 years earlier. She had been healthy and had no allergies or food intolerances.

Infertility treatment was initiated with ovarian stimulation 6 weeks before the patient presented, and she became pregnant approximately 2 weeks later. At this time, she commenced intramuscular progesterone therapy as part of luteal phase support. This seemed to trigger a febrile response with a temperature of up to 38[degrees]C (100.4[degrees]F), mild constitutional symptoms, and dry cough. Her symptoms diminished over the ensuing few weeks.

Seven days before admission, the patient was instructed by her fertility physician to double the dose of intramuscular progesterone. The next day, she had a temperature of up to 39[degrees]C (102.2[degrees]F), progressive fatigue, asthenia, anorexia, and dyspnea. She was hospitalized with a diagnosis of pneumonia and was treated with...

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