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...7 time-points for 98,995 metropolitan French-women (primarily teachers) ages 40-65. The 12-year study ended in 2002. A recent analysis of 80,377 post-menopausal women followed for an average of 8.1 years examined breast cancer rates among women using different hormone regimens. (1)
In France, the most commonly used estrogen for menopausal hormone therapy is estradiol, either taken orally or topically. Topical estrogen is applied to the skin through a patch, cream, or gel, and is much more popular in France than the oral version. Women with a uterus must add a progestagen hormone to topical and oral estrogen, because estrogen alone increases their risk of endometrial (uterine) cancer. There's a wider variety of progestagens used in French menopausal hormone therapies than in U.S. therapies but, in both countries, progestagens are usually used orally.
In the [E.sub.3]N study, 2,354 women were diagnosed with invasive breast cancer. Compared to women who never took any menopausal hormones, taking estrogen alone increased the breast cancer risk. The majority of progestagens...
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National Women's Health Network., March 01, 2008
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