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Burst of autoimmunity with the emergence of Primary Sjogren syndrome, cholestatic autoimmune hepatitis and latent autoimmune diabetes of adults (LADA).

Publication: Southern Medical Journal
Publication Date: 01-SEP-06 		Format: Online
Delivery: Immediate Online Access
Full Article Title: Burst of autoimmunity with the emergence of Primary Sjogren syndrome, cholestatic autoimmune hepatitis and latent autoimmune diabetes of adults (LADA).(Letter to the editor)

Article Excerpt
To the Editor: Primary Sjogren syndrome (pSS) is a systemic autoimmune disorder characterized by the simultaneous presence of keratoconjunctivitis sicca and xerostomia in the absence of other connective tissue diseases. Although pSS is an autoimmune exocri-nopathy, the involvement of nonexo-crine organs, such as the liver, kidneys and lungs, has been reported. Autoimmune hepatitis (AIH) and primary biliary cirrhosis are the most common liver diseases coinciding with pSS. (1) Cholestasis is a rare finding in AIH. Latent autoimmune diabetes in adults (LADA) is the type of diabetes in adults which is initially noninsulin requiring but with immune markers of Type 1 diabetes that often progress to insulin dependence. (2) We report a patient who presented with the symptoms and findings of pSS, cholestatic AIH and LADA at the same time.

A 43-year-old woman was admitted to our hospital with the complaints of abdominal...

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