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Missing link?: alachlor and semen quality.

Publication: Environmental Health Perspectives
Publication Date: 01-OCT-05
Format: Online
Delivery: Immediate Online Access
Full Article Title: Missing link?: alachlor and semen quality.(Perspectives/ Correspondence)

Article Excerpt
The article by Swan et al. (2003) suggested that alachlor exposure was linked to reduced sperm quality in fertile men; after publication of the article, Monsanto (St. Louis, MO) began a detailed examination of the issue because the findings were entirely unexpected and inconsistent with both our information and the extensive published literature on alachlor. Most surprisingly, alachlor mercapturate (AM) was reportedly found in the urine of 92% of study participants in Columbia, Missouri. Because this metabolite arises exclusively from exposure to the parent compound, few, if any, detects would be expected based on declining alachlor use (National Agricultural Statistics Service 2005) and our detailed understanding of its biological and environmental properties (Feng et al. 1994). Also, extensive water monitoring studies submitted to the U.S. Environmental Protection Agency (EPA) have shown that parent alachlor occurs very infrequently in both potable wells...

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