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Article Excerpt
-Provides Patent Protection for Lead Anti-Cancer Clinical Candidate SF 1126 and Follow-on Compounds- -Company Also Presents New Preclinical Data Reinforcing Growing Body of Promising Results in a Variety of Cancer Models-
INDIANAPOLIS, Sept. 28 /PRNewswire/ -- Semafore Pharmaceuticals, Inc., an emerging leader in small molecule cancer therapies addressing critical cell signaling pathways, today announced that the U.S. Patent Office has issued PI-3 kinase inhibitor prodrugs, U.S. Patent No. 6,949,537. This patent covers Semafore's lead clinical candidate, SF1126, and other prodrug compositions of the widely studied PI3K inhibitor, LY294002, that Semafore is evaluating as a novel therapy for cancer and other diseases. The PI3K pathway is a critical intercept point at the center of the mammalian cell signaling system, controlling multiple functions that contribute to the development and spread of cancer, including angiogenesis, apoptosis, migration, invasion and metastasis, and is mutated in cancer more frequently than any other...
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