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SCOLR Pharma Reports Raloxifene Study Validates Benefits of CDT(R) Platform for Challenging Drugs.

Publication: Business Wire
Publication Date: 29-AUG-05 		Format: Online
Delivery: Immediate Online Access

Article Excerpt
BELLEVUE, Wash. -- SCOLR Pharma, Inc. (AMEX:DDD) announced today that it has successfully completed pilot bioavailability testing in Canada of its Controlled Delivery Technology (CDT(R)) raloxifene tablets. The trial data demonstrates that SCOLR's patented amino acid CDT-based platform can be a viable alternative to currently utilized solubility and permeability-enhancing practices.

Raloxifene hydrochloride is the active ingredient in Evista(R), Eli Lilly's immediate release tablets for osteoporosis. Evista uses a different solubilization technology. In 2004, Eli Lilly (NYSE:LLY) reported over $1 billion in global Evista sales. Commercially available Evista 60 milligram (mg.) immediate release tablets served as the external reference control for SCOLR Pharma's pilot study.

The pilot testing consisted of a 20-subject, randomized, five-way crossover, open-label, fasting trial. It compared three 45 mg. formulations of the CDT-based raloxifene with two controls -- Evista and an internal control. SCOLR Pharma previously reported that an animal evaluation of an amino acid-based CDT-raloxifene...

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