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Procyon reports enhanced cross-resistance profile of its lead HIV Protease inhibitor, PL-100; TICKER: PBP (TSX).

Publication: PR Newswire
Publication Date: 03-FEB-05 		Format: Online
Delivery: Immediate Online Access

Article Excerpt
Procyon Biopharma Inc. (TSX: PBP) reported today that it has completed a larger viral cross- resistance study in collaboration with the South San Francisco-based company ViroLogic Inc. to compare the resistance profile of its lead HIV protease inhibitor PL-100 with commercially available protease inhibitors (PIs). The results showed that PL-100 and its back-up analogue PL-337 had the most favorable cross-resistance profile of all the PIs studied as measured by the median fold change in IC50 as well as percentage of the strains requiring a fold-change of the drug greater than either 2.5 or 10 as described below.

The current study report was based on 63 HIV resistant strains including the 14 resistant strains that were part of the panel reported previously by Procyon in November 2003. The selected viral strains were challenged with PL- 100...

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