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Primary aldosteronism in type 1 diabetes mellitus.

Publication: Southern Medical Journal
Publication Date: 01-NOV-04 		Format: Online - approximately 880 words
Delivery: Immediate Online Access
Full Article Title: Primary aldosteronism in type 1 diabetes mellitus.(Letters to the Editor)(Letter to the Editor)

Article Excerpt
To the Editor: Alterations in the renin-angiotensin-aldosterone system have been documented in patients with diabetes mellitus. Their blood potassium levels are usually high or in normal ranges. The syndrome of hyporeninemic hypoaldosteronism or renal tubular acidosis (RTA) type IV is most frequently seen in diabetes mellitus, usually with concomitant nephropathy. It is characterized by hyperkalemia and low levels of plasma renin activity (PRA) and aldosterone without significant changes in glucocorticoid secretion. We present the case of a diabetic patient with hypokalemia and low renin levels with inappropriately high plasma aldosterone concentration, suggestive of primary aldosteronism.

A 62-year-old white male, known to have type 1 diabetes mellitus for over 30 years, was referred for persistent hypokalemia of 6 months' duration. He was an adopted child. Past medical history included paranoid schizophrenia, cataract...

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