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...(1 -3). Whether these and 13 other recognized military and civilian nonfatal ischemic events among vaccinees were associated with smallpox vaccination is unclear. The same NYCBOH strain was used in 1947 to vaccinate approximately six million New York City (NYC) residents (80% of the population) during a 4-week period (April 4-May 2) after a smallpox outbreak (Figure 1). To determine whether smallpox vaccination increased the risk for cardiac death in 1947, the NYC Department of Health and Mental Hygiene (DOHMH) analyzed data from NYC death certificates during that period. This report summarizes the results of that analysis, which found no increases in cardiac, atherosclerotic, or all-cause deaths. The findings are consistent with a growing body of evidence suggesting that ischemic cardiac deaths observed after the 2003 campaign might have been unrelated to vaccine.
[FIGURE 1 OMITTED]
In April 2003, data were extracted from NYC death certificates filed during March-June 1947 and from the same period in 1946 and 1948 (N = 81,529). DOHMH estimated the relative risk for cardiac deaths in the period after vaccination compared with other periods, adjusting for secular trends. The number of adults vaccinated on each of the 29 days of the vaccination campaign was estimated by using DOHMH records and articles from local newspapers and magazines (4). Death certificates issued in NYC during March-June in 19461948 were obtained from the NYC Municipal Archives. Date of death,...
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