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West Nile virus meningitis in patient with common variable immunodeficiency.

Publication: Emerging Infectious Diseases
Publication Date: 01-OCT-03 		Format: Online
Delivery: Immediate Online Access
Full Article Title: West Nile virus meningitis in patient with common variable immunodeficiency.(Letters)

Article Excerpt
To the Editor: Infection by West Nile virus (WNV) was first recognized in the Western Hemisphere in 1999 in New York (1). Subsequently, this mosquito-borne flavivirus has spread westward and has emerged as an important cause of infectious meningoencephalitis in the United States (2). In September 2002, during a WNV epidemic in Michigan (2), a 38-year-old woman with common variable immunodeficiency (CVID) sought treatment at the University of Michigan Hospital with acute WNV-associated meningitis. Although persons with CVID are at increased risk for enteroviral meningoencephalitis, a greater susceptibility to arthropodborne flavivirus infections has not been reported.

The patient had a history of recurrent sino-pulmonary infections and gastrointestinal giardiasis and salmonellosis; at 33 years of age, she was diagnosed with CVID that has been subsequently treated with intravenous immunoglobulin (IVIG) every 3 weeks. She was in her usual state of health until 5 days before admission, when she...

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