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Depomed Initiates Phase II Trial With Once Daily Diuretic Furosemide GR.

Publication: Business Wire
Publication Date: 06-JAN-04 		Format: Online
Delivery: Immediate Online Access

Article Excerpt
Business Editors/Health/Medical Writers

BIOWIRE2K

MENLO PARK, Calif.--(BUSINESS WIRE)--Jan. 6, 2004

Study Will Use invivodata eDiary to Capture Patient Self-Report Data

Depomed, Inc. (NASDAQ: DEPO) today announced that it has begun a Phase II clinical trial under its IND for Furosemide GR(TM), a once daily, controlled-release formulation of the leading diuretic furosemide based on Depomed's proprietary Gastric Retention (GR(TM)) drug delivery system. The trial will evaluate the effectiveness of Furosemide GR as a controlled-release diuretic in alleviating the build up of fluid that is often associated with congestive heart failure (CHF). In a previous Phase I trial conducted in healthy volunteers, Furosemide GR achieved bioavailability, diuresis, sodium excretion and total fluid output comparable to that of immediate release furosemide (LASIX(R)), but with less urinary urgency and less initial frequency.

"Applying our gastric retention technology to furosemide gives us the opportunity to evaluate the efficacy of our GR System...

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