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Investigators at Amgen, Inc. have published new data on chromatography.

Publication: Biotech Week
Publication Date: 04-NOV-09
Format: Online
Delivery: Immediate Online Access

Article Excerpt
"Two major aggregation pathways observed in an IgG2 molecule are described. Different aggregate species generated by long-term incubation of the antibody at 37 degrees C were collected by a semi-preparative size exclusion chromatography method," scientists in the United States report (see also Chromatography).

"These purified species were analyzed extensively by denaturing size-exclusion chromatography methods. The major aggregation pathway at low pH...

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