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UPDATE: FDA Approves Pralatrexate for Treatment of Peripheral T-Cell Lymphoma; Drug Discovered and Developed by SRI International, Memorial Sloan-Kettering Cancer Center, and Southern Research Institute.

Publication: PR Newswire
Publication Date: 28-SEP-09 		Format: Online
Delivery: Immediate Online Access

Article Excerpt
MENLO PARK, Calif. and NEW YORK and BIRMINGHAM, Ala., Sept. 28 /PRNewswire/ -- The U.S. Food & Drug Administration has announced the approval of pralatrexate for the treatment of relapsed or refractory peripheral T-cell lymphoma (PTCL). Research on drugs of this class began in the 1950s at SRI International. A subsequent scientific collaboration among SRI International, Memorial Sloan-Kettering Cancer Center, and Southern Research Institute led to clinical trials on related compounds conducted by Memorial Sloan-Kettering Cancer Center starting in the 1980s. Pralatrexate was ultimately identified as a viable clinical candidate and was licensed to Allos Therapeutics for further development in 2002.

Francis M. Sirotnak, Ph.D., one of the inventors of pralatrexate and a molecular pharmacologist and Memorial Sloan-Kettering Cancer Center Member Emeritus said, "In the laboratory and in clinical trials at Sloan-Kettering, we were able to demonstrate that this was a therapeutically active drug. After many years of research and drug development it is very rewarding to see...

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