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Article Excerpt
Cardioxyl Pharmaceuticals, Inc., a clinical stage pharmaceutical company developing therapeutic agents for the treatment of cardiovascular disease, has announced the initiation of a Phase I/IIa dose-escalation study of lead drug candidate, CXL-1020, for the treatment of acute decompensated heart failure (ADHF). The study has already begun enrollment, and the first patient was dosed in June 2009.
The Phase I/IIa dose-escalation study will evaluate the safety and tolerability of CXL-1020 and specific effects on non-invasive hemodynamic parameters in patients with chronic stable heart failure. The study will also evaluate the pharmacokinetics of CXL-1020.
Chris Kroeger, MD, president and CEO of Cardioxyl Pharmaceuticals, commented, "There is significant clinical need for a safe and effective therapy to treat acute decompensated heart failure patients that would enhance both diastolic and systolic function, while concomitantly reducing vascular resistance." Kroeger continued,...
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