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Peregrine Pharmaceuticals Awarded Broad New U.S. Patent for Vascular Imaging Applications of Its PS-Targeting Platform.

Publication: PR Newswire
Publication Date: 24-JUN-09 		Format: Online
Delivery: Immediate Online Access

Article Excerpt
-- New Claims Cover Use of Phosphatidylserine-Targeting Antibodies to Image Solid Tumors and Other Malignancies --

-- Supported by Published Data Showing Utility of PS-Targeting Antibodies for the Molecular Imaging of Cancer --

TUSTIN, Calif., June 24 /PRNewswire-FirstCall/ -- Peregrine Pharmaceuticals, Inc. today reported the issuance of a U.S. patent with broad claims covering vascular imaging applications for phosphatidylserine (PS)-targeting antibodies. The patent represents the first broad coverage of imaging claims under Peregrine's PS-targeting platform, which includes Peregrine's lead antibody bavituximab. PS is a phospholipid that becomes exposed on the surface of tumor blood vessel cells. Since PS is typically not exposed on the surface of normal tissues, it represents a unique target for the vascular imaging of tumors and tumor metastases in patients with cancer.

"PS-targeting antibodies such as bavituximab preferentially bind to tumor blood vessels, which makes them ideal vehicles for imaging the tumor vasculature,"...

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