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New expression systems create opportunities for innovators, CMOs and product developers: but will concerns about regulatory issues, royalties and return on past investments continue to impede industry adoption?

Publication: Pharmaceutical Technology Europe
Publication Date: 01-JUN-09 		Format: Online
Delivery: Immediate Online Access

Article Excerpt
There may well be a pending revolution in biopharmaceutical expression systems. Nearly 50% of biomanufacturers today are demanding a whole lot more from their primary expression systems than they have during the past 30 years. (1) Although there have been substantial improvements in classic expression systems with the years, there has been a general lack of interest in adopting newer platform technologies. The result is that nearly all biotherapeutic products manufactured today use much the same old, familiar technologies--Esherichia coli, Chinese hamster ovary and the yeast Saccharomyces cerevisiae.

Biopharmaceutical industry in limbo

The need for innovation in the biopharmaceutical sector has a greater urgency than ever before. Our new report, Biopharmaceutical Expression Systems: Current and Future Manufacturing Platforms, explains that biopharmaceutical companies are only now beginning to address strategic innovation at the outset of their drug development processes. This is a recent shift, despite the fact that a range of promising technologies have been made available for...

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